Association of relative telomere length with cardiovascular disease in a large chronic kidney disease cohort: The GCKD study. Issue 2 (October 2015)

• Record Type: Journal Article
• Authors: Raschenberger, Julia; Kollerits, Barbara; Titze, Stephanie; Köttgen, Anna; Bärthlein, Barbara; Ekici, Arif B.; Forer, Lukas; Schönherr, Sebastian; Weissensteiner, Hansi; Haun, Margot; Wanner, Christoph; Eckardt, Kai-Uwe; Kronenberg, Florian
• Is Part Of: Atherosclerosis. Volume 242:Issue 2(2015)
• Page Start: 529
• Page End: 534
• Publication Date: 2015-10
• Subjects: Telomere length -- Cardiovascular disease -- Chronic kidney disease -- High-risk population; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2015.08.020
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Background: Chronic kidney disease (CKD) affects 10–15% of the general population and affected individuals are at an increased risk for cardiovascular disease (CVD). Since telomere length is considered to be involved in biological aging, we tested whether relative telomere length (RTL) might be a marker for these two diseases. Methods: The German Chronic Kidney Disease (GCKD) study is an ongoing prospective cohort study including patients with CKD of moderate severity. RTL was measured by qPCR in 4955 out of 5217 GCKD patients at baseline. Results: RTL was distributed in the cohort with a mean ± SD of 0.95 ± 0.19. CVD was present in 1266 patients. Each decrease of RTL by 0.1 unit was associated with a higher probability for prevalent CVD: OR = 1.06, 95% CI 1.02–1.11, p = 0.007 (adjusted for age, sex, eGFR, BMI, ln-CRP, smoking, hypertension, diabetes, and lipids). Similar findings were observed for history of specific CVD entities, such as coronary artery disease (OR = 1.05, p = 0.025), myocardial infarction (OR = 1.08, p = 0.013) and percutaneous transluminal coronary angioplasty (OR = 1.06, p = 0.032). The strongest associations were found for interventions at the carotid arteries (OR = 1.25, p = 0.001) as well as aortic aneurysms (OR = 1.22, p = 0.001). Conclusions: In the presence of CKD there is a significant association between shorter RTL and CVD manifestations. RTL appears to be a marker reflecting changes in homeostasis associated with CKD that may contribute to the excess CVD risk. Highlights: Kidney disease is associated with an increased risk for cardiovascular disease (CVD). Relative telomere length (RTL) is considered to be involved in aging and CVD. We tested whether RTL is associated with CVD in patients with kidney disease. Data are from the German Chronic Kidney Disease study including 4955 patients. Shorter RTL was associated with prevalent CVD and aortic aneurysms.