A biodegradable 3D woven magnesium-based scaffold for orthopedic implants. (1st July 2022)

• Record Type: Journal Article
• Authors: Xue, Ju; Singh, Srujan; Zhou, Yuxiao; Perdomo-Pantoja, Alexander; Tian, Ye; Gupta, Nehali; Witham, Timothy F; Grayson, Warren L; Weihs, Timothy P
• Is Part Of: Biofabrication. Volume 14:Number 3(2022)
• Publication Date: 2022-07-01
• Subjects: biodegradable metal -- magnesium alloy -- 3D weave -- biomaterial scaffold; Biomedical engineering -- Periodicals; Tissue engineering -- Periodicals; Biomedical materials -- Microstructure -- Periodicals; Bioengineering -- Periodicals; 610.28
• DOI: 10.1088/1758-5090/ac73b8
• Languages: English
• ISSNs: 1758-5082

Abstract

Abstract: Porous Magnesium (Mg) is a promising biodegradable scaffold for treating critical-size bone defects, and as an essential element for human metabolism, Mg has shown sufficient biocompatibility. Its elastic moduli and yield strengths are closer to those of cortical bone than common, inert metallic implants, effectively reducing stress concentrations around host tissue as well as stress shielding. More importantly, Mg can degrade and be absorbed in the human body in a safe and controlled manner, thereby reducing the need for second surgeries to remove implants. The development of porous Mg scaffolds via conventional selective laser melting techniques has been limited due to Mg's low boiling point, high vapor pressures, high reactivity, and non-ideal microstructures in additively manufactured parts. Here we present an exciting alternative to conventional additive techniques: 3D weaving with Mg wires that have controlled chemistries and microstructures. The weaving process offers high throughput manufacturing as well as porous architectures that can be optimized for stiffness and porosity with topology optimization. Once woven, we dip-coat the weaves with polylactic acid to enhance their strength and corrosion resistance. Following fabrication, we characterize their mechanical properties, corrosion behavior, and cell compatibility in vitro, and we use an intramuscular implantation model to evaluate their in vivo corrosion behavior and tissue response.