Eutectic Salt Catalyzed Environmentally Benign and Highly Efficient Biginelli Reaction. (29th April 2012)

• Record Type: Journal Article
• Authors: Azizi, Najmadin; Dezfuli, Sahar; Hahsemi, Mohmmad Mahmoodi
• Other Names: Capriati V. Academic Editor.; Fernandes R. A. Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 2012(2012)
• Publication Date: 2012-04-29
• Subjects: Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/2012/908702
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : A simple deep eutectic solvent based on tin (II) chloride was used as a dual catalyst and environmentally benign reaction medium for an efficient synthesis of 3, 4-dihydropyrimidin-2(1H)-one derivatives, from aromatic and aliphatic aldehydes, 1, 3-dicarbonyl compounds, and urea in good-to-excellent yields and short reaction time. This simple ammonium deep eutectic solvent, easily synthesized from choline chloride and tin chloride, is relatively inexpensive and recyclable, making it applicable for industrial applications.