Zinc Oxide Nanoparticles Catalyzed Condensation Reaction of Isocoumarins and 1, 7-Heptadiamine in the Formation of Bis-Isoquinolinones. (12th March 2012)

• Record Type: Journal Article
• Authors: Krishnakumar, Varadhan; Mohan Kumar, Kesarla; Mandal, Badal Kumar; Khan, Fazlur-Rahman Nawaz
• Other Names: Patil N. T. Academic Editor.; Shibata I. Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 2012(2012)
• Publication Date: 2012-03-12
• Subjects: Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/2012/619080
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : The diversified bis-isoquinolinones were obtained in two steps, utilizing homophthalic acid and various acid chlorides providing 3-substituted isocoumarins in the first step which on further condensation with 1, 7-heptadiamine involving C–N bond formation from the lactone in the presence of 10 mol% zinc oxide nanoparticles (ZnO NPs) (<150 nm) afforded the desired bis-isoquinolinones in high yield and purity. The synthesized compounds were then characterized using FTIR, 1 H NMR, 13 C NMR, and HRMS techniques.