Expressions of MMPs and TIMP-1 in Gastric Ulcers May Differentiate H. pylori-Infected from NSAID-Related Ulcers. (1st May 2012)

• Record Type: Journal Article
• Authors: Cheng, Hsiu-Chi; Yang, Hsiao-Bai; Chang, Wei-Lun; Chen, Wei-Ying; Yeh, Yi-Chun; Sheu, Bor-Shyang
• Other Names: Karmiris Konstantinos Academic Editor.
• Is Part Of: TheScientificWorldjournal. Volume 2012(2012)
• Publication Date: 2012-05-01
• Subjects: Science -- Periodicals; Technology -- Periodicals; Medicine -- Periodicals; 505
• DOI: 10.1100/2012/539316
• Languages: English
• ISSNs: 2356-6140

Abstract

Abstract : Background . Two major causes of gastric ulcers are Helicobacter pylori ( H. pylori ) infection and nonsteroidal anti-inflammatory drug (NSAID) use. Aims . This study aimed to determine if there were different expressions of matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) between H. pylori -infected and NSAID-related ulcers. Methods . The 126 gastric ulcer patients ( H. pylori infected n = 46 ; NSAID related n = 30 ; combined with two factors n = 50 ) provided ulcer and nonulcer tissues for assessment of MMP-3, -7, and -9 and TIMP-1 expression by immunohistochemical staining. Results . Gastric ulcer tissues had significantly higher MMP-3, -7, and -9 and TIMP-1 expressions than nonulcer tissues (P < 0.05 ). H. pylori -infected gastric ulcers had even higher MMP-7, MMP-9, and TIMP-1 expressions in epithelial cells than NSAID-related gastric ulcers (P < 0.05 ). In patients with the two combined factors, gastric ulcers expressed similar proportions of antral ulcers and MMP-7 and MMP-9 intensities to NSAID-related gastric ulcers, but lower MMP-9 and TIMP-1 than H. pylori -infected gastric ulcers (P < 0.05 ). Conclusions. H. pylori -infected gastric ulcers express higher MMP-7, MMP-9, and TIMP-1 than NSAID-related ulcers. In patients with the two combined factors, ulcer location and MMP-7 and MMP-9 intensities are similar to NSAID use.