Association of Daily Alcohol Intake, Volumetric Breast Density, and Breast Cancer Risk. Issue 2 (4th February 2021)

• Record Type: Journal Article
• Authors: Rustagi, Alison S; Scott, Christopher G; Winham, Stacey J; Brandt, Kathleen R; Norman, Aaron D; Jensen, Matthew R; Shepherd, John A; Hruska, Carrie; Heine, John J; Pankratz, Vernon S; Kerlikowske, Karla; Vachon, Celine M
• Is Part Of: JNCI cancer spectrum. Volume 5:Issue 2(2021)
• Publication Date: 2021-02-04
• DOI: 10.1093/jncics/pkaa124
• Languages: English
• ISSNs: 2515-5091

Abstract

Abstract: High alcohol intake and breast density increase breast cancer (BC) risk, but their interrelationship is unknown. We examined whether volumetric density modifies and/or mediates the alcohol-BC association. BC cases (n = 2233) diagnosed from 2006 to 2013 in the San Francisco Bay area had screening mammograms 6 or more months before diagnosis; controls (n = 4562) were matched on age, mammogram date, race or ethnicity, facility, and mammography machine. Logistic regression was used to estimate alcohol-BC associations adjusted for age, body mass index, and menopause; interaction terms assessed modification. Percent mediation was quantified as the ratio of log (odds ratios [ORs]) from models with and without density measures. Alcohol consumption was associated with increased BC risk (2-sided P trend = .004), as were volumetric percent density (OR = 1.45 per SD, 95% confidence interval [CI] = 1.36 to 1.56) and dense volume (OR = 1.30, 95% CI = 1.24 to 1.37). Breast density did not modify the alcohol-BC association (2-sided P > .10 for all). Dense volume mediated 25.0% (95% CI = 5.5% to 44.4%) of the alcohol-BC association (2-sided P = .01), suggesting alcohol may partially increase BC risk by increasing fibroglandular tissue.