Frequency-selective signal enhancement by a passive dual coil resonator for magnetic particle imaging. (7th June 2022)

• Record Type: Journal Article
• Authors: Pantke, Dennis; Mueller, Florian; Reinartz, Sebastian; Philipps, Jonas; Mohammadali Dadfar, Seyed; Peters, Maximilian; Franke, Jochen; Schrank, Franziska; Kiessling, Fabian; Schulz, Volkmar
• Is Part Of: Physics in medicine & biology. Volume 67:Number 11(2022)
• Publication Date: 2022-06-07
• Subjects: magnetic particle imaging -- passive receive coil -- signal enhancement; Biophysics -- Periodicals; Medical physics -- Periodicals; 610.153
• DOI: 10.1088/1361-6560/ac6a9f
• Languages: English
• ISSNs: 0031-9155

Abstract

Abstract: Objective. Magnetic particle imaging (MPI) visualizes the spatial distribution of magnetic nanoparticles. MPI already provides excellent temporal and good spatial resolution, however, to achieve translation into clinics, further advances in the fields of sensitivity, image reconstruction and tracer performance are needed. In this work, we propose a novel concept to enhance the MPI signal and image resolution by a purely passive receive coil insert for a preclinical MPI system. Approach. The passive dual coil resonator (pDCR) provides frequency-selective signal enhancement. This is enabled by the adaptable resonance frequency of the pDCR network, which is galvanically isolated from the MPI system and composed of two coaxial solenoids connected via a capacitor. The pDCR aims to enhance frequency components related to high mixing orders, which are crucial to achieve high spatial resolution. Main Results. In this study, system matrix measurements and image acquisitions of a resolution phantom are carried out to evaluate the performance of the pDCR compared to the integrated receive unit of the preclinical MPI and a dedicated rat-sized receive coil. Frequency-selective signal increase and spatial resolution enhancement are demonstrated. Significance. Common dedicated receive coils come along with noise-matched receive networks, which makes them costly and difficult to reproduce. The presented pDCR is a purely passive coil insert that gets along without any additional receive electronics. Therefore, it is cost-efficient, easy-to-handle and adaptable to other MPI scanners and potentially other applications providing the basis for a new breed of passive MPI receiver systems.