Back Cover: In Vitro Selection of a DNA Aptamer Targeting Degraded Protein Fragments for Biosensing (Angew. Chem. Int. Ed. 20/2020). Issue 20 (6th April 2020)

• Record Type: Journal Article
• Authors: Liu, Meng; Wang, Jiayi; Chang, Yangyang; Zhang, Qiang; Chang, Dingran; Hui, Christy Y.; Brennan, John D.; Li, Yingfu
• Is Part Of: Angewandte Chemie international edition. Volume 59:Issue 20(2020)
• Page Start: 7968
• Page End: 7968
• Publication Date: 2020-04-06
• Subjects: aptamers -- biosensors -- in vitro selection -- paper-based analytical devices -- protein degradation; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.202004665
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : A DNA aptamer targeting naturally degraded protein fragments was selected by M. Liu, J. D. Brennan, Y. Li, and co‐workers in their Communication on page 7706 . The aptamer binds a degraded form of toxin B from Clostridium difficile and can detect this protein fragment in human stool. This method offers a way to discover DNA aptamers that cannot be selected using purified proteins, thus expanding the practical utility of DNA aptamers in clinical diagnosis.