Photo‐Controlled Reversible Microtubule Assembly Mediated by Paclitaxel‐Modified Cyclodextrin. Issue 28 (21st June 2018)

• Record Type: Journal Article
• Authors: Zhang, Ying‐Ming; Zhang, Ni‐Yuan; Xiao, Kui; Yu, Qilin; Liu, Yu
• Is Part Of: Angewandte Chemie international edition. Volume 57:Issue 28(2018)
• Page Start: 8649
• Page End: 8653
• Publication Date: 2018-06-21
• Subjects: cyclodextrin -- microtubules -- molecular recognition -- photo-responsiveness -- supramolecular assembly; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201804620
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The design and construction of multi‐stimuli‐responsive supramolecular nanoassemblies that can mimic and regulate the fundamental biological processes have become a focus of interest in supramolecular chemistry. In this work, a perfect combination has been achieved between naturally occurring microtubules and artificially macrocyclic receptors. The self‐assembling morphology of microtubules can be photo‐tuned by the host–guest interaction of paclitaxel‐modified β‐cyclodextrin (PTX‐CD) and photochromic arylazopyrazole (PTX‐AAP). Moreover, the supramolecularly aggregated microtubules in a cellular environment can induce a pronounced cell morphological change and cell death. This supramolecular approach based on the secondary PTX‐AAP⊂PTX‐CD complexation provides us a facile method to reversibly control the intertubular aggregation behaviors of microtubules, which may bring new perspectives in the treatment of diseases related to improper protein aggregation. Abstract : A microtubule assembly can be photo‐switched by the host–guest interaction of paclitaxel‐modified cyclodextrin and photochromic arylazopyrazole, thus producing different morphological changes and cytotoxicity in cells.