Enantioselective Intermolecular Heck and Reductive Heck Reactions of Aryl Triflates, Mesylates, and Tosylates Catalyzed by Nickel. (9th December 2020)

• Record Type: Journal Article
• Authors: Huang, Xiaolei; Teng, Shenghan; Chi, Yonggui Robin; Xu, Wenqiang; Pu, Maoping; Wu, Yun‐Dong; Zhou, Jianrong Steve
• Is Part Of: Angewandte Chemie. Volume 133:Number 6(2021)
• Page Start: 2864
• Page End: 2868
• Publication Date: 2020-12-09
• Subjects: aryl halides -- aryl sulfonates -- Heck reaction -- nickel catalysis -- reductive Heck reaction; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202011036
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Nickel‐catalyzed intermolecular Heck reaction of cycloalkenes proceeds well with aryl triflates, mesylates and tosylates in excellent enantiomeric ratios. The asymmetric reductive Heck reaction also works with a 2‐cyclopentenone ketal, which is equivalent to conjugate arylation of the enone itself. Abstract : Nickel catalysts efficiently promote enantioselective Heck reaction of aryl triflates, mesylates and tosylates in excellent ee values. Asymmetric reductive Heck reaction with a ketal of 2‐cyclopentenone also proceeds well, which is equivalent to conjugate arylation of the enone itself.