Cover Picture: Carbon–Carbon Bond Formation via Catalytically Generated Aminocarbene Complexes: Rhodium‐Catalyzed Hydroaminative Cyclization of Enynes with Secondary Amines (Angew. Chem. Int. Ed. 29/2020). Issue 29 (4th June 2020) - Takano, Shotaro
Abstract : Heteroatom‐stabilized transition‐metal carbene complexes are useful building blocks for organic synthesis, but their catalytic generation from substrates with common functional groups is still challenging. In their Communication on page 11754, F. Kakiuchi et al. report a novel hydroaminative cyclization of enynes with secondary amines catalyzed by phosphine‐quinolinolato rhodium complexes to form cyclic enamines through the catalytic construction of an aminocarbene intermediate.