Advantage of 68Ga-PSMA PET/CT on Postradiotherapy Response Assessment of Juvenile Nasal Angiofibroma. (February 2021)

• Record Type: Journal Article
• Authors: Sakthivel, Pirabu; Thakar, Alok; Thankarajan Arunraj, Sreedharan; Bhalla, Ashu Seith; Kumar, Rakesh
• Is Part Of: Clinical nuclear medicine. Volume 46:Number 2(2021)
• Publication Date: 2021-02
• Subjects: angiofibroma -- PSMA PET/CT -- juvenile nasopharyngeal angiofibroma -- MRI; Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000003359
• Languages: English
• ISSNs: 0363-9762

Abstract

Abstract : Abstract: Prostate-specific membrane antigen (PSMA) is universally expressed in the endothelial cells of tumor-associated neovasculature of juvenile nasopharyngeal angiofibroma. Functional 68 Ga-PSMA PET/CT also enables easier differentiation of the residual tumor from postoperative changes. An 18-year-old man with the residual intracranial disease received radiotherapy after surgery. In PSMA PET/CT imaging, uptake was noted initially only in the residual disease, and the same was absent after successful response to radiotherapy, unlike contrast MRI, which showed persistent enhancement. Functional 68 Ga-PSMA PET/CT may be a very useful tool clinically for identifying early responses to radiotherapy compared with conventional structural imaging.