Extra-virgin olive oil phenols hydroxytyrosol and hydroxytyrosol acetate, down-regulate the production of mediators involved in joint erosion in human synovial cells. (September 2017)

• Record Type: Journal Article
• Authors: Rosillo, María Ángeles; Sánchez-Hidalgo, Marina; Castejón, María Luisa; Montoya, Tatiana; González-Benjumea, Alejandro; Fernández-Bolaños, José G.; Alarcón-de-la-Lastra, Catalina
• Is Part Of: Journal of functional foods. Volume 36(2017)
• Page Start: 27
• Page End: 33
• Publication Date: 2017-09
• Subjects: DMSO dimethyl sulfoxide -- HTy hydroxytyrosol -- HTy-Ac hydroxytyrosol-acetate -- MMPs metalloproteases -- RA rheumatoid arthritis -- SRB sulforhodamine B -- SFs synovial fibroblasts -- TNF-α tumour necrosis factor alpha; EVOO -- Inflammatory response -- Olive oil -- Rheumatoid arthritis -- Synovial fibroblasts; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2017.06.041
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Phenolic compounds are typically included in Mediterranean diet. Phenolic compounds may have beneficial roles on immuno-inflammatory diseases like RA. We evaluated the effects of two phenol compounds on SW982 cell line. SW982 cell line is a useful in vitro tool to study inflammation in AR. EVOO phenols modulated joint erosion in human synovial cells. Abstract: The hallmark of rheumatoid arthritis (RA) pathology is characterized by both hyperproliferation of synovial fibroblasts (SFs) and massive infiltration of inflammatory immune cells. This study was conducted to evaluate the efficacy of hydroxytyrosol (HTy) and hydroxytyrosol-acetate (HTy-Ac) in regulating IL-1β-induced production of metalloproteases (MMPs) and proinflammatory cytokines in human synovial cell line. Treatment with HTy or HTy-Ac significantly inhibited IL-1β-induced MMPs, tumour necrosis factor (TNF)-α and IL-6 production. IL-1β-up regulation COX-2 and mPGE-1 was downregulated by HTy and HTy-Ac. IL-1β-induced MAPKs phosphorylation and NF-κB activation were inhibited by HTy and HTy-Ac. These results suggest that these EVOO phenols reduce the production of proinflammatory mediators in SW982 cells; these protective effects could be related to the inhibition of MAPKs and NF-κB signalling pathways. Thus, HTy and HTy-Ac might be promising targets for the prevention and management of diseases associated with overactivation of synovial fibroblasts, like RA.