Biomarkers in acute respiratory distress syndrome. Issue 1 (February 2021)

• Record Type: Journal Article
• Authors: Jabaudon, Matthieu; Blondonnet, Raiko; Ware, Lorraine B.
• Is Part Of: Current opinion in critical care. Volume 27:Issue 1(2021)
• Publication Date: 2021-02
• Subjects: acute respiratory distress syndrome -- biomarker -- pathogenesis -- predictive enrichment -- prognostic enrichment; Critical care medicine -- Periodicals; 616.028
• DOI: 10.1097/MCC.0000000000000786
• Languages: English
• ISSNs: 1070-5295

Abstract

Abstract : Purpose of review: This article provides an overview of protein biomarkers for acute respiratory distress syndrome (ARDS) and their potential use in future clinical trials. Recent findings: The protein biomarkers studied as indices of biological processes involved in the pathogenesis of ARDS may have diagnostic and/or prognostic value. Recently, they also proved useful for identifying ARDS phenotypes and assessing heterogeneity of treatment effect in retrospective analyses of completed clinical trials. Summary: This article summarizes the current research on ARDS biomarkers and provides insights into how they should be integrated as prognostic and predictive enrichment tools in future clinical trials.