Cell-based immunotherapy in gynecologic malignancies. Issue 1 (February 2021)

• Record Type: Journal Article
• Authors: Kamat, Kalika; Krishnan, Venkatesh; Berek, Jonathan S.; Dorigo, Oliver
• Is Part Of: Current opinion in obstetrics and gynecology. Volume 33:Issue 1(2021)
• Publication Date: 2021-02
• Subjects: chimeric antigen receptor T-cell therapy -- gynecologic malignancies -- immunotherapy -- macrophage-based cell therapy -- natural killer-cell-based therapy -- tumor-infiltrating lymphocytes; Obstetrics -- Periodicals; Gynecology -- Periodicals; Genital Diseases, Female -- Indexes; Genital Diseases, Female -- Periodicals; Obstetrics -- Indexes; Obstetrics -- Periodicals; Review Literature -- Periodicals; 618.005
• DOI: 10.1097/GCO.0000000000000676
• Languages: English
• ISSNs: 1040-872X

Abstract

Abstract : Purpose of review: To provide an update on cell-based immunotherapies in solid tumors particularly in gynecological cancers. Recent findings: Recent clinical trial results demonstrate safety and tolerability of different cell therapies in gynecological cancers. Novel approaches, such as harnessing the cells of the innate immune system are also under investigation in a phase I trial. Summary: Cell-based therapies are gaining widespread attention as evidenced by the increasing number of clinical trials encompassing both, innate and adaptive cells to target gynecological cancers. A majority of these therapeutic approaches are well tolerated and show promising results in early trials.