Daily administration of paraprobiotic Lactobacillus gasseri CP2305 ameliorates chronic stress-associated symptoms in Japanese medical students. (September 2017)

• Record Type: Journal Article
• Authors: Nishida, Kensei; Sawada, Daisuke; Kuwano, Yuki; Tanaka, Hiroki; Sugawara, Tomonori; Aoki, Yumeko; Fujiwara, Shigeru; Rokutan, Kazuhito
• Is Part Of: Journal of functional foods. Volume 36(2017)
• Page Start: 112
• Page End: 121
• Publication Date: 2017-09
• Subjects: ANOVA analysis of variance -- ANCOVA analysis of covariance -- BSS Bristol Stool Scale -- CNS central nervous system -- EEG electroencephalograph -- GHQ General Health Questionnaire -- HADS Hospital Anxiety and Depression Scale -- IBS irritable bowel syndrome -- LAB lactic acid bacteria -- miRNA micro-ribonucleic acids -- PSQI Pittsburgh Sleep Quality Index -- QOL quality of life -- STAI State Trait Anxiety Inventory; Lactobacillus gasseri CP2305 -- Chronic psychological stress -- Stress-related behaviours -- Sleep quality -- Stress-responsive microRNAs; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2017.06.031
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Paraprobiotic Lactobacillus gasseri CP2305 improved stress and sleep quality. CP2305 intake lowered salivary cortisol concentrations. Parasympathetic nerve activity was dominant after CP2305 intake. CP2305 intake improved the bowel habits of subjects suffering from chronic stress. CP2305 intake suppressed the expression of stress-responsive miRNAs. Abstract: Administration of Lactobacillus gasseri CP2305 for 4 weeks improved stress-associated behaviours in healthy young adults and clinical symptoms in patients with irritable bowel syndrome. The present study was designed to confirm the stress-relieving effects of heat-inactivated, washed CP2305 (paraprobiotic CP2305) on 69 sixth-year medical students (40 males and 29 females) preparing to take the national examination for medical practitioners. Administration of the paraprobiotic CP2305 for 12 weeks significantly improved sleep quality assessed by both the Pittsburgh Sleep Quality Index and a one-channel sleep electroencephalogram during the pre-examination period compared with that of the placebo administration. The paraprobiotic CP2305 administration also prevented increases in basal salivary cortisol release and expression of stress-responsive microRNAs (miR-144 and miR-144 ∗ ). In addition to the improvement in parasympathetic nerve activity, the paraprobiotic CP2305 normalized the bowel habits under the stressful conditions. Based on these results, we propose that paraprobiotic CP2305 may be used as a para-psychobiotic.