Ethnicity-dependent effects of Zinc finger 804A variant on schizophrenia: a systematic review and meta-analysis. (February 2021)

• Record Type: Journal Article
• Authors: Wang, Dandan; Wang, Yewei; Chen, Yan; Yu, Lingfang; Fang, Xinyu; Liu, Ruimei; Wu, Zenan; Zhang, Chen
• Is Part Of: Psychiatric genetics. Volume 31:Number 1(2021)
• Publication Date: 2021-02
• Subjects: meta-analysis -- Rs1344706 -- schizophrenia -- zinc finger 804A; Mental illness -- Genetic aspects -- Periodicals; Periodicals; 616.89042
• DOI: 10.1097/YPG.0000000000000275
• Languages: English
• ISSNs: 0955-8829

Abstract

Abstract : Objectives: Previous studies and meta-analysis indicated that rs1344706 was associated with schizophrenia in European population, whereas the conclusions in other populations were disputed. To further explore whether the allele A of rs1344706 would increase the risk of schizophrenia in different populations and update the original meta-analysis, we conducted a systematic review and meta-analysis worldwide. Methods: A literature search was performed in PubMed, Embase, Cochrane Library, PsycINFO and Web of Science (up to 10 July 2019) according to the inclusion criteria. Results: A total of 27 articles were included. Our meta-analysis showed an association between rs1344706 and schizophrenia in total populations [ P = 0.000; odds ratio (OR) = 1.105; 95% confidence interval (CI), 1.048–1.165], Europe population ( P = 0.025; OR = 1.108; 95% CI, 1.013–1.222) and Asian population( P = 0.005; OR = 1.094; 95% CI, 1.027–1.164). Conclusions: Our findings suggested that the risk of single nucleotide polymorphism rs1344706 A-allele may increase the risk of schizophrenia worldwide. Also, this ethnicity-dependent effects of ZNF804A variant on schizophrenia may be related to the opposite allele direction. But to elucidate the underlying biological mechanism, further studies with large participant populations are needed. Abstract : Supplemental Digital Content is available in the text.