Characterization and antioxidant activity of β-carotene loaded chitosan-graft-poly(lactide) nanomicelles. (6th March 2015)

• Record Type: Journal Article
• Authors: Ge, Wenjiao; Li, Dong; Chen, Meiwan; Wang, Xiaohui; Liu, Shijie; Sun, Runcang
• Is Part Of: Carbohydrate polymers. Volume 117(2015)
• Page Start: 169
• Page End: 176
• Publication Date: 2015-03-06
• Subjects: β-C β-carotene -- CS-g-PLA chitosan-g-poly(lactide) -- ROP ring-opening polymerization -- β-C/M β-carotene loaded micelles -- DPPH 2, 2-diphenyl-1-picrylhydrazyl -- FRAP ferric reducing antioxidant power -- EE entrapment efficiency -- LC loading content; Chitosan -- Self-assemble -- Nanomicelles -- β-Carotene -- Antioxidant activity; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2014.09.056
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: The self-assembled chitosan-based micelles were used for encapsulation of β-carotene. The β-carotene loaded chitosan nanomicelles possessed good stability. The β-carotene loaded micelles showed significantly improved antioxidant activities. Abstract: β-Carotene (β-C) is a well-established natural antioxidant agent, but its poor water-solubility, low chemical stability and low bioavailability limit its application in food, pharmaceuticals and cosmetics industries. Thus it is critical to develop an efficient method to improve the water solubility and stability of β-C. In this research, amphiphilic chitosan-graft-poly (lactide) (CS-g-PLA) copolymer was synthesized via a homogeneous ring-opening polymerization (ROP) in ionic liquid. The obtained CS-g-PLA copolymer was able to self-assemble into about 14 nm micelles in water at low concentration, and β-C loaded micelles (β-C/M) had low β-C degradation after 15 days. The antioxidant properties of the β-C/M were investigated by the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method and ferric reducing antioxidant power (FRAP) method, respectively. Significantly improved antioxidant activity was observed for β-C/M in compare with free β-C. The aqueous dispersion of β-C/M has potential to be applied in the field of functional food and cosmetics.