Enhancement in the osteogenesis and angiogenesis of calcium phosphate cement by incorporating magnesium-containing silicates. Issue 15 (1st August 2022)

• Record Type: Journal Article
• Authors: Yuan, Xinyuan; Wu, Tingting; Lu, Teliang; He, Fupo; Chen, Peng; Ma, Ning; Ye, Jiandong
• Is Part Of: Ceramics international. Volume 48:Issue 15(2022)
• Page Start: 21543
• Page End: 21555
• Publication Date: 2022-08-01
• Subjects: Calcium phosphate cement -- Akermanite -- Diopside -- Forsterite -- Osteogenesis -- Angiogenesis; Ceramics -- Periodicals; Céramique industrielle -- Périodiques; Ceramics; Periodicals; Electronic journals; 666
• DOI: 10.1016/j.ceramint.2022.04.118
• Languages: English
• ISSNs: 0272-8842

Abstract

Abstract: Based on the good osteogenic and angiogenic effects of silicon and magnesium elements, three types of micro-nano magnesium-containing silicates (MS), including akermanite (Ake, Ca2 MgSi2 O7 ), diopside (Dio, CaMgSi2 O6 ) and forsterite (For, Mg2 SiO4 ), were incorporated into calcium phosphate cement (CPC) to improve its osteogenic and angiogenic performances for clinical application. In this present work, the physicochemical properties, osteogenesis and angiogenesis of MS/CPCs (Ake/CPCs, Dio/CPCs and For/CPCs) were investigated systematically and comparatively. The results showed that all MS/CPCs had good biomineralization and significantly stimulated the osteogenic differentiation of mBMSCs and angiogenic differentiation of HUVECs, respectively. Besides, the stimulating effects were related to not only the category of MS, but also the content of MS. The For/CPCs had a good angiogenic property but their initial setting times were beyond 60 min. The Dio/CPCs showed the lowest biological performance among the three groups of MS/CPCs due to the lower ion release (Si and Mg). The Ake was the ideal modifier that could provide CPC with appropriate physicochemical properties, better osteogenesis and angiogenesis. Simultaneously, a higher addition (10 wt%) of akermanite resulted in the best potential to bone regeneration. Taken together, this research provides an effective approach to improve the overall performance of CPC, and 10Ake/CPC is of great promising prospect in bone repair. Graphical abstract: Image 1