Associations between prenatal exposure to polybrominated diphenyl ethers and physical growth in a seven year cohort study. (September 2022)

• Record Type: Journal Article
• Authors: Hu, Yi; Lu, Qi; Huang, Chuican; Gao, Yu; Tian, Ying; Fan, Lichun; Liu, Shijian
• Is Part Of: Chemosphere. Volume 303:Part 1(2022)
• Publication Date: 2022-09
• Subjects: Polybrominated diphenyl ethers -- Children -- Physical growth -- Weight -- Height -- Linear mixed models; AIDS acquired immunodeficiency syndrome -- BFRs brominated flame retardants -- BMI body mass index -- CIs confidence intervals -- BPA bisphenol A -- DOHaD the Developmental Origins of Health and Disease theory -- GAMs generalized additive models -- GH growth hormone -- IGF-1 insulin-like growth factor 1 -- LOD limit of detection -- Pb lead -- PBDEs polybrominated diphenyl ethers -- PCBs polychlorinated biphenyls -- PND postnatal day -- POPs persistent organic pollutants -- SDs standard deviations -- THs thyroid hormones; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2022.135049
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Although evidence suggests that prenatal exposure to polybrominated diphenyl ethers (PBDEs) alter offspring's physical growth, most studies rely upon physical growth at a single timepoint, and little is known regarding their longitudinal effects over time. In the current study, we determined the associations between prenatal PBDEs exposure and child physical growth by following up 207 mother-child pairs from the Laizhou Wan Birth Cohort (LWBC) from pregnancy until the children were seven years old. Child physical growth including weight, height, and body mass index (BMI) was assessed at birth, and at one, two and seven years of age. Prenatal exposure to PBDEs was quantified by measuring eight PBDE congeners (BDE-28, BDE-47, BDE-85, BDE-99, BDE-100, BDE-153, BDE-154, and BDE-183) in maternal serum samples collected upon hospital admission for delivery. Linear mixed models were applied to examine the associations between prenatal PBDEs exposure and repeated measures of child physical growth, and to determine whether these associations were modified by child's sex. Our findings indicated that BDE-28, BDE-85, BDE-153, BDE-183, and Σ7 PBDEs were positively associated with child weight z-score; and that BDE-28, BDE-47, BDE-85, BDE-99, BDE-153, and Σ7 PBDEs were positively associated with child height z-score. In addition, these associations were modified by the child's sex as reflected by pronounced positive associations among boys, while negative associations were noted among girls. In conclusion, our findings indicated the sex-specific associations between prenatal PBDE exposures and child physical growth during the first seven years of life. Graphical abstract: Image 1 Highlights: Prenatal PBDEs exposure was detected in 207 pregnant women in LWBC, China. Child physical growth was assessed at birth, 1, 2, and 7 years. PBDEs were positively associated with child weight and height z-scores. Effects of PBDEs exposure on child physical growth were more pronounced in boys.