Electrochemical detection of nicotine at a carbon Nanofiber-Poly(amidoamine) dendrimer modified glassy carbon electrode. (September 2022)

• Record Type: Journal Article
• Authors: Sebokolodi, Tsholofelo I.; Sipuka, Dimpo S.; Muzenda, Charles; Nkwachukwu, Oluchi V.; Nkosi, Duduzile; Arotiba, Omotayo A.
• Is Part Of: Chemosphere. Volume 303:Part 1(2022)
• Publication Date: 2022-09
• Subjects: Nicotine -- Carbon nanofiber -- poly(amidoamine) dendrimer -- Electrodeposition -- Electrochemical sensor; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2022.134961
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Development of electrochemical sensors for important drugs such nicotine (an addictive drug) is important for the society. This study reports the electrochemical detection of nicotine at a carbon nanofiber/poly (amidoamine) dendrimer modified glassy carbon electrode. The carbon nanofiber (CNF) modified GCE was prepared by drop-coating followed by the electrodeposition of generation 4 poly (amidoamine) succinamic acid dendrimer (PAMAM) to form the sensor - CNF-PAMAM GCE. Characterization of prepared materials and modified electrodes was carried out using Fourier transmission infrared spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, cyclic voltammetry, electrochemical impedance spectroscopy (EIS) and differential pulse voltammetry (DPV). The CNF-PAMAM composite was confirmed by microscopy. A marked reduction in charge transfer resistance and increase in current of the CNF-PAMAM GCE in comparison to the bare electrode showed a synergic improvement electrochemical response because of the CNF-PAMAM nanocomposite. The CNF-PAMAM demonstrated an enhanced performance in the oxidation of nicotine in comparison to the bare GCE by shifting the anodic potential E p a of nicotine from 0.9 V to 0.8 V. The electrochemical sensor achieved a detection limit (LOD) of 0.02637 μM in the concentration range of 0.4815–15.41 μM of nicotine in 0.1 M PBS at pH 7.5. The sensor ability to determine nicotine in real samples was assessed in cigarettes obtaining recovery percentages of 88.00 and 97.42%. The sensor demonstrated selectivity toward nicotine in the presence of interferences. Finally, the method was validated by ultraviolet–visible spectroscopy analysis. Highlights: We prepared a carbon nanofiber (CNF)/dendrimer (PAMAM) based sensor for nicotine. The PAMAM was electrodeposited on a CNF modified (by drop coating) carbon electrode. The CNF-PAMAM platform enhanced the electrooxidation of nicotine. The electrochemical sensor has a detection limit of 0.1646 μM for nicotine. The sensor was applied in real cigarette sample and method was validated.