Oyster polysaccharides ameliorate intestinal mucositis and improve metabolism in 5-fluorouracil-treated S180 tumour-bearing mice. (15th March 2021)

• Record Type: Journal Article
• Authors: Cai, Bingna; Pan, Jianyu; Chen, Hua; Chen, Xin; Ye, Ziqing; Yuan, Huabiao; Sun, Huili; Wan, Peng
• Is Part Of: Carbohydrate polymers. Volume 256(2021)
• Publication Date: 2021-03-15
• Subjects: Oyster polysaccharide -- 5-FU -- Intestinal mucositis -- Gut microbiota -- Metabolism; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.117545
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: CHP preventd occurrence and development of 5-FU-induced intestinal mucositis. CHP regulated intestinal microbiota via TLRs signaling pathway. CHP increased the concentrations of propionic acid and n -butyric acid. CHP reversed the changes in nutritional and energy metabolism in model mice. CHP increased the tumour inhibition rate of 5-FU and improved mental state. Abstract: The purpose of this study was to investigated the potential role of gut microbiota in protecting the intestinal barrier and improving nutritional metabolism in 5-FU-treated S180 tumour-bearing mice after treatment with oyster polysaccharide (CHP). CHP, with an α -(1→4) d -linked glucose backbone and (→4, 6)- α -d -Glc-(1→) branches every 4.7 residues on average, increased the villus height, crypt depth, mucosa thickness, villus surface area and V/C ratio; decreased the expression of IL-1β, IL-6, and TNF-α; and even restored the TP, ALB, PA, TRF, IgA, IgM and IgG levels to normal levels. All these factors are related to CHP increasing the propionic acid- and butyric acid-producing microorganisms and decreasing the production of Bacteroides, Prevotellaceae_UCG-001 and Rikenellaceae_RC9_gut_group, thus affecting the TLRs signalling pathway. In conclusion, CHP attenuates 5-FU-induced intestinal mucositis and malnutrition by regulating gut microbiota, and can improve the prognosis of patients receiving chemotherapy.