170. Characterization of Appropriate Antibiotic Prescribing for Pediatric Respiratory Tract Infections: Setting the Stage for Stewardship. (26th November 2018)

• Record Type: Journal Article
• Authors: Hersh, Adam L; Thorell, Emily; Liu, Diane; Zhang, Mingyuan; Madaras-Kelly, Karl; Samore, Matthew; Hicks, Lauri; Fleming-Dutra, Katherine
• Is Part Of: Open forum infectious diseases. Volume 5(2018)Supplement 1
• Page Start: S76
• Page End: S76
• Publication Date: 2018-11-26
• Subjects: Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofy210.183
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Background: Inappropriate antibiotic use includes prescribing for antibiotic inappropriate diagnoses and use of broad-spectrum instead of narrow-spectrum therapies and contributes to adverse events and antibiotic resistance. To guide the design and implementation of antibiotic stewardship interventions in a network of pediatric clinics, we sought to characterize appropriate antibiotic prescribing for children diagnosed with uncomplicated respiratory infections. Methods: Retrospective cohort study of visits by children to one of 31 primary care or six urgent care clinics in a university healthcare system between January 1, 2016 and December 31, 2017. Two outcomes were used to characterize antibiotic prescribing: (1) percentage of antibiotic inappropriate diagnoses (bronchitis, bronchiolitis, upper respiratory infection) that were prescribed an antibiotic; (2) percentage of visits with a diagnosis for acute otitis media (AOM), sinusitis, or pharyngitis prescribed first-line recommended antibiotics (amoxicillin or penicillin). Children with a documented penicillin allergy or antibiotic prescriptions in the previous 30 days were excluded. Chi-square tests were used to compare prescribing between settings. Results: Among 117, 279 total visits examined, 16, 760 (14%) were for antibiotic inappropriate diagnoses, 5, 912 (5%) for AOM, 844 (1%) for sinusitis and 4, 912 (4%) for pharyngitis. Only 3% (95% CI: 2.9–3.4) of antibiotic inappropriate diagnoses were prescribed antibiotics. The percent of visits for AOM, sinusitis, and pharyngitis prescribed first-line antibiotics ranged from 27% (95% CI: 21–33) for sinusitis in urgent care to 91% (95% CI: 90–92) for pharyngitis in urgent care (figure). Differences in appropriate prescribing by setting were observed for AOM ( P < 0.01) and sinusitis ( P < 0.01). Conclusion: In this network of pediatric practices, we found minimal evidence of unnecessary antibiotic use for respiratory infections but substantial underuse of first-line therapy for sinusitis, especially in urgent care settings. Stewardship interventions designed to reinforce existing practices for antibiotic-inappropriate conditions and promote greater use of appropriate first-line therapies are planned for this setting. Disclosures: All authors: No reported disclosures.