1105. Vibriocidal Titer Variation and Likelihood of Protection in Children Compared With Adults in a Cholera Endemic Area. (26th November 2018)

• Record Type: Journal Article
• Authors: Ritter, Alaina; Chowdhury, Fahima; Becker, Rachel; Bhuiyan, Taufiq; Khan, Ashraful; Ryan, Edward T; Calderwood, Stephen B; LaRocque, Regina; Harris, Jason; Qadri, Firdausi; Weil, Ana
• Is Part Of: Open forum infectious diseases. Volume 5(2018)Supplement 1
• Page Start: S331
• Page End: S331
• Publication Date: 2018-11-26
• Subjects: Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofy210.939
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Background: Vibrio cholerae, the causative agent of cholera, is responsible for significant morbidity and mortality worldwide. Children less than 5 years old have the highest disease burden of cholera in endemic areas. While children develop serum vibriocidal antibody responses to cholera vaccines, they derive less protection from vaccination compared with adults. The aim of our study was to determine whether the vibriocidal immune responses to V. cholerae infection are equally accurate as markers of protection in all age groups. Methods: Cholera patients and their household contacts, who are known to be at high risk of V. cholerae infection, were enrolled between 2001 and 2017 in Dhaka, Bangladesh. Baseline vibriocidal titers were measured at the time of enrollment of household contacts, and participants were followed prospectively for development of V. cholerae infection. Results: We studied 50 contacts < 5 years old ("young children"), 228 contacts 5–16 years old ("older children"), and 548 contacts > 16 years old ("adults"). The baseline serum vibriocidal titer was higher in contacts who remained uninfected from all age groups than in contacts who developed cholera during the follow-up period (young children: P = 0.0092; older children: P = 0.0003, adults: P = 0.0012). Conclusion: We found that higher vibriocidal antibody titers were associated with protection against V. cholerae infection across all three age categories. These findings may help increase our understanding of the protective immune response against V. cholerae infection and have importance for future vaccine development strategies. Acknowledgments: This research was supported by Massachusetts General Hospital training grant T32AI007061. Disclosures: All authors: No reported disclosures.