Cell therapy during machine perfusion. (24th November 2020)

• Record Type: Journal Article
• Authors: Thompson, Emily R.; Connelly, Chloe; Ali, Simi; Sheerin, Neil S.; Wilson, Colin H.
• Is Part Of: Transplant international. Volume 34:Number 1(2021)
• Page Start: 49
• Page End: 58
• Publication Date: 2020-11-24
• Subjects: cell therapy -- machine perfusion -- preservation -- regenerative medicine -- transplant; Transplantation of organs, tissues, etc -- Periodicals; 617.95405
• DOI: 10.1111/tri.13780
• Languages: English
• ISSNs: 0934-0874

Abstract

Summary: There has been increasing use of organs from extended criteria or donation after circulatory death donors to meet the demands of the transplant waiting list. Over the past decade, there has been considerable progress in technologies to preserve organs prior to transplantation to improve the function of these marginal organs. This has led to the development of normothermic machine perfusion, whereby an organ is perfused with warmed, oxygenated blood and nutrients to resume normal physiological function in an isolated ex‐vivo platform. With this advance in preservation comes significant opportunities to recondition, repair and regenerate organs prior to transplantation using cellular therapies. This review aims to discuss the possibilities of machine perfusion technology; highlighting the potential for organ‐directed reconditioning and the future avenues for investigation in this field.