Synthesis of Cu-doped 2D-WS2 nanosheet-based nano-antibiotic materials for inhibiting E. Coli and S. aureus bacterial strains. (2nd March 2022)

• Record Type: Journal Article
• Authors: Ashfaq, Mohammad; Talreja, Neetu; Chauhan, Divya; Viswanathan, Mangalaraja Ramalinga
• Is Part Of: New journal of chemistry. Volume 46:Number 12(2022)
• Page Start: 5581
• Page End: 5587
• Publication Date: 2022-03-02
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/d1nj05931a
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A new class of nano-antibiotic materials must be developed to treat bacterial infectious diseases. In this context, the synthesizing Cu-metal incorporated WS2 nanosheet (Cu–WS2 -NS)-based antibiotic materials might overcome such associated issues. Abstract : The emergence of bacterial resistance is increasing continuously due to the misuse of antibiotics that results in difficulty controlling the bacterial infection or the lack of treatment. Therefore, a new class of antibiotic or nano-antibiotic materials must be developed to treat bacterial infectious diseases. In this context, the present study focuses on synthesizing Cu-metal incorporated WS2 nanosheet (Cu–WS2 -NS)-based antibiotic materials. The Cu–WS2 -NS was synthesized via a liquid exfoliation process, followed by the incorporation of Cu-metal using a microwave process. The as-prepared WS2 -NS and Cu–WS2 -NS based antibiotics were characterized via SEM, EDS, and FT-IR analysis. The as-prepared WS2 -NS and Cu–WS2 -NS based antibiotic materials showed high biocompatibility or insignificant toxicity (∼0.78% and 3.7%) against erythrocyte cells, respectively. The as-prepared WS2 -NS and Cu–WS2 -NS based antibiotic materials effectively inhibited or killed (99.99%) both E. Coli and S. aureus bacterial strains. The antibacterial activity of the Cu–WS2 -NS based antibiotic materials was mainly due to the Cu metal that binds with the sulfide group of WS2 -NS. Interestingly, the Cu–WS2 -NS-based antibiotic materials showed superior or comparable antibiotic ability to that of commercially available Ampicillin antibiotics. Therefore, the as-prepared Cu–WS2 -NS based antibiotic materials might be potential emerging materials to treat infectious diseases or control bacterial infections.