The fine-needle aspiration cytology and clinical findings of Kikuchi–Fujimoto disease in pediatric patients: a retrospective clinical study. (1st April 2022)

• Record Type: Journal Article
• Authors: Naoi, Yuto; Tachibana, Tomoyasu; Wani, Yoji; Hotta, Machiko; Haruna, Katsuya; Komatsubara, Yasutoshi; Kuroda, Kazunori; Fushimi, Soichiro; Nagatani, Tami; Kataoka, Yuko; Nishizaki, Kazunori; Sato, Yasuharu; Ando, Mizuo
• Is Part Of: Acta oto-laryngologica. Volume 142:Number 3/4(2022)
• Page Start: 340
• Page End: 344
• Publication Date: 2022-04-01
• Subjects: Kikuchi–Fujimoto disease -- pediatric lymphadenitis -- fine-needle aspiration cytology; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.1080/00016489.2022.2040744
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Background: Histological evaluation of lymph node is crucial for the definitive diagnosis of Kikuchi–Fujimoto disease (KFD). However, lymph node biopsy under local anesthesia is often difficult in pediatric patients. Objectives: We evaluated cytological findings for pediatric patients with prolonged cervical lymphadenitis clinically suggestive of KFD and investigated the clinical characteristics of patients diagnosed with KFD by fine-needle aspiration cytology (FNAC). Methods: This retrospective clinical study included 58 Japanese pediatric patients with cervical lymphadenitis who underwent FNAC. Results: Cytological diagnosis was KFD for 22 and suspicion of KFD for 11 patients. The remaining 25 patients were diagnosed with non-specific lymphadenitis (NSL). Tenderness was independently associated with a higher frequency of both KFD in narrow and broad senses, compared with NSL ( p = .009; p = .038). The percentage of patients who underwent FNAC within 28 days from symptom onset tended to be higher among patients with KFD in a narrow sense than those with NSL ( p = .052). Conclusion: This study indicated that the period from symptom onset to FNAC (<28 days) and the symptom of tenderness were associated with the cytological diagnosis of KFD.