The ER-mitochondria tether at the hub of Ca2+ signaling. Issue 17 (October 2020)

• Record Type: Journal Article
• Authors: Vecellio Reane, Denis; Rizzuto, Rosario; Raffaello, Anna
• Is Part Of: Current opinion in physiology. Issue 17(2020)
• Page Start: 261
• Page End: 268
• Publication Date: 2020-10
• Subjects: Physiology -- Periodicals; Physiological Phenomena; Periodical; Fulltext; Internet Resources; Periodicals; 571
• DOI: 10.1016/j.cophys.2020.08.013
• Languages: English
• ISSNs: 2468-8673

Abstract

Abstract : Inter-organelle contacts are emerging as crucial hubs in cell signaling. Among these, the long known ER-mitochondria tethers can be considered a reference model for these communication structures. Here, signal crosstalk at the interface of ER and mitochondria occurs thanks to lipids exchange and Ca 2+ flux across these specialized structures. How this signal is modulated depends on the compositions of the proteins that are engaged at these areas of membrane proximity. These proteins modulate the activity of Ca 2+ channels and regulate contact structure remodeling in response to cellular cues. In this review, we highlight the molecular aspects of the ER-mitochondria contacts and how they impact on Ca 2+ signaling and thus on cell physiology.