Calcium regulation of T cell metabolism. Issue 17 (October 2020)

• Record Type: Journal Article
• Authors: Wang, Yin-Hu; Tao, Anthony Y; Vaeth, Martin; Feske, Stefan
• Is Part Of: Current opinion in physiology. Issue 17(2020)
• Page Start: 207
• Page End: 223
• Publication Date: 2020-10
• Subjects: Physiology -- Periodicals; Physiological Phenomena; Periodical; Fulltext; Internet Resources; Periodicals; 571
• DOI: 10.1016/j.cophys.2020.07.016
• Languages: English
• ISSNs: 2468-8673

Abstract

Abstract : T cells are an essential component of the immune system that provide antigen-specific acute and long lasting immune responses to infections and tumors, ascertain the maintenance of immunological tolerance and, on the flipside, mediate autoimmunity in a variety of diseases. The activation of T cells through antigen recognition by the T cell receptor (TCR) results in transient and sustained Ca 2+ signals that are shaped by the opening of Ca 2+ channels in the plasma membrane and cellular organelles. The dynamic regulation of intracellular Ca 2+ concentrations controls a variety of T cell functions on the timescale of seconds to days after signal initiation. Among the more recently identified roles of Ca 2+ signaling in T cells is the regulation of metabolic pathways that control the function of many T cell subsets. In this review, we discuss how Ca 2+ regulates several metabolic programs in T cells such as the activation of AMPK and the PI3K-AKT-mTORC1 pathway, aerobic glycolysis, mitochondrial metabolism including tricarboxylic acid (TCA) cycle function and oxidative phosphorylation (OXPHOS), as well as lipid metabolism.