The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. Issue 1 (March 2015)

• Record Type: Journal Article
• Authors: Muse, Evan D.; Feldman, David I.; Blaha, Michael J.; Dardari, Zeina A.; Blumenthal, Roger S.; Budoff, Matthew J.; Nasir, Khurram; Criqui, Michael H.; Cushman, Mary; McClelland, Robyn L.; Allison, Matthew A.
• Is Part Of: Atherosclerosis. Volume 239:Issue 1(2015)
• Page Start: 101
• Page End: 108
• Publication Date: 2015-03
• Subjects: Atherosclerotic heart disease -- Risk stratification -- Resistin -- Adipokines; Arteriosclerosis -- Periodicals; Electronic journals; 616.136
• DOI: 10.1016/j.atherosclerosis.2014.12.044
• Languages: English
• ISSNs: 0021-9150

Abstract

Abstract: Objective : To describe the relationship between circulating resistin levels and cardiovascular diseases (CVD) and all-cause death in a multi-ethnic cohort. Methods and results : We studied 1913 participants from the Multi-Ethnic Study of Atherosclerosis with measurements of plasma resistin levels. Absolute proportions experiencing new-onset atrial fibrillation (AF), atherosclerotic CVD (myocardial infarction, angina, resuscitated cardiac arrest, stroke), heart failure (HF), and all-cause death were calculated for each quartile of resistin. We used adjusted Cox proportional regression modeling resistin as a continuous variable per standard deviation of log-transformed resistin and secondarily as a categorical variable using resistin quartiles. Results were stratified by sex and race/ethnicity. The mean age of the population was 64.5 ± 10 years with half being female and a median resistin concentration of 15.1 ng/mL (11.9–19.1). Mean follow-up time was 7.2 ± 1.8 years. There was a graded increase in the occurrence of all outcomes across increasing quartiles of resistin. Modeled as a continuous variable, after adjustment for anthropomorphic measures, traditional risk factors, markers of inflammation, and other adipokines, significant associations were noted for HF (HR 1.4, CI 1.0–2.0), hard and all CVD (HR 1.3, 1.1–1.7 and 1.3, 1.1–1.6, respectively), and CHD (HR 1.31, 1.0–1.6), but not for AF or death. Significant interaction terms were noted between resistin and race, with Hispanic race/ethnicity showing the strongest relationship between resistin and outcomes. Conclusions : In an ethnically diverse population without known CVD at baseline, there was a strong, independent association between higher resistin levels and incident CVD, CHD and HF. Highlights: We examined the association of plasma resistin levels and cardiovascular disease. Events included AF, MI, angina, resuscitated cardiac arrest, stroke, HF and death. Increased resistin was associated with HF, atherosclerotic CVD (all & hard) and CHD. Associations remained significant after adjustment for traditional CV risk factors. The association of resistin and CV events was greatest in the Hispanic population.