Detection of the Omicron variant of SARS-CoV-2 in international travelers returning to Venezuela. Issue 48 (July 2022)

• Record Type: Journal Article
• Authors: Jaspe, Rossana C.; Sulbaran, Yoneira; Loureiro, Carmen L.; Moros, Zoila C.; Marulanda, Ernestina; Bracho, Francis; Ramírez, Nieves A.; Canonico, Yeilis; D'Angelo, Pierina; Rodríguez, Lieska; Castro, Julio; Liprandi, Ferdinando; Rangel, Héctor R.; Pujol, Flor H.
• Is Part Of: Travel medicine and infectious disease. Issue 48(2022)
• Publication Date: 2022-07
• Subjects: COVID-19 -- SARS-CoV-2 -- Omicron variant of concern -- Mutations -- International travels; Travel -- Health aspects -- Periodicals; Communicable diseases -- Periodicals; Tropical medicine -- Periodicals; 610.5
• DOI: 10.1016/j.tmaid.2022.102326
• Languages: English
• ISSNs: 1477-8939

Abstract

Abstract: Background: By the end of 2021, the SARS-CoV-2 Variant of Concern (VOC) Delta was predominant in most of the world. At the end of November, the Omicron variant was first detected in South Africa. This variant was immediately classified as VOC, due to the explosive increase of cases in South Africa, and the great number of mutations exhibited by this new lineage. Since then, Omicron VOC displaced Delta one in almost every country. Venezuela implemented in May 2021 molecular testing of all the passengers arriving at Venezuelan airports. Methods: In this study, we analyzed the presence of variants of SARS-CoV-2 in those positive samples, by sequencing a small fragment of the Spike genomic region. Results: The Omicron variant was found in passengers arriving to Venezuela from the beginning of December. Complete genome analysis confirmed the presence of the Omicron VOC. The detection of this VOC coincided with an unprecedented increase in the frequency of passengers with positive nucleic acid testing. Conclusions: Genomic surveillance of samples for international travelers returning to Venezuela allowed us to rapidly detect the introduction of the Omicron variant in the country. Highlights: Venezuela requires COVID-19 molecular testing when arriving to the country. Variants of SARS-CoV-2 were analyzed by sequencing a small genomic region. The Omicron variant was found in passengers from the beginning of December. Omicron detection coincided with an unprecedented increase in positive samples.