Mammalian antiviral RNAi is on the move. (26th April 2022)

• Record Type: Journal Article
• Authors: Schierhorn, Kristina L; Sanchez‐David, Raul Y; Maillard, Pierre V
• Is Part Of: EMBO journal. Volume 41:Number 11(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-04-26
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.2022111210
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract : Recent work reported the existence of a mammalian cell‐autonomous antiviral defence based on RNA interference (RNAi), which relies on the accumulation of virus‐derived small interfering RNAs (vsiRNAs) to guide the degradation of complementary viral RNAs. In a new study, Zhang et al (2022) find that, in infected mice, vsiRNAs can enter the bloodstream via their incorporation into extracellular vesicles (EVs) and confer sequence‐specific antiviral activity to recipient cells, thus indicating that mammalian antiviral RNAi participates in both cell‐autonomous and non‐cell‐autonomous host defence. Abstract : A recent study shows that virus‐derived small interfering RNAs (vsiRNAs) can enter the bloodstream in infected mice and confer sequence‐specific antiviral activity to recipient cells.