Hearing voices in the resting brain: A review of intrinsic functional connectivity research on auditory verbal hallucinations. (August 2015)

• Record Type: Journal Article
• Authors: Alderson-Day, Ben; McCarthy-Jones, Simon; Fernyhough, Charles
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 55(2015:Aug.)
• Page Start: 78
• Page End: 87
• Publication Date: 2015-08
• Subjects: Resting state -- Default mode network -- Voice-hearing -- Inner speech -- Schizophrenia; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2015.04.016
• Languages: English
• ISSNs: 0149-7634

Abstract

Highlights: Alterations to resting connectivity may underpin auditory verbal hallucinations (AVH). Resting connectivity in left temporal cortex shows trait and state alterations. Future AVH research would benefit from an agreed analysis protocol for resting data. Abstract: Resting state networks (RSNs) are thought to reflect the intrinsic functional connectivity of brain regions. Alterations to RSNs have been proposed to underpin various kinds of psychopathology, including the occurrence of auditory verbal hallucinations (AVH). This review outlines the main hypotheses linking AVH and the resting state, and assesses the evidence for alterations to intrinsic connectivity provided by studies of resting fMRI in AVH. The influence of hallucinations during data acquisition, medication confounds, and movement are also considered. Despite a large variety of analytic methods and designs being deployed, it is possible to conclude that resting connectivity in the left temporal lobe in general and left superior temporal gyrus in particular are disrupted in AVH. There is also preliminary evidence of atypical connectivity in the default mode network and its interaction with other RSNs. Recommendations for future research include the adoption of a common analysis protocol to allow for more overlapping datasets and replication of intrinsic functional connectivity alterations.