Constructing virus-like SiOx/CeO2/VOx nanozymes for 1064 nm light-triggered mild-temperature photothermal therapy and nanozyme catalytic therapy. Issue 2 (8th December 2021)

• Record Type: Journal Article
• Authors: Zhao, Ruoxi; Zhang, Rui; Feng, Lili; Dong, Yushan; Zhou, Jialing; Qu, Songnan; Gai, Shili; Yang, Dan; Ding, He; Yang, Piaoping
• Is Part Of: Nanoscale. Volume 14:Issue 2(2022)
• Page Start: 361
• Page End: 372
• Publication Date: 2021-12-08
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/d1nr06128c
• Languages: English
• ISSNs: 2040-3364

Abstract

Abstract : We prepared virus-like SCV-PEG with superior ability to enter cells. It showed POD-mimic catalytic activity and a mild-temperature PTT effect, and the produced VO 2+ can bind HSP60 to promote PTT. Abstract : The construction of nanoplatforms with combined photothermal properties and cascading enzymatic activities has become an active area of anticancer research. However, the overheating of photothermal therapy (PTT) and the specific properties of tumor microenvironment (TME) greatly impaired the therapeutic efficiency. Herein, we rationally fabricated a virus-like SiO x /CeO2 /VO x (SCV) nanoplatform for 1064 nm near-infrared (NIR) triggered mild-temperature PTT and nanozyme catalytic therapy. Firstly, the virus-like shape of SiO x /CeO2 /VO x made it favorable for cell adhesion and improved its phagocytosis in cells, and the SCV generated an effective PTT effect upon 1064 nm laser irradiation. Particularly, the produced VO 2+ in TME could be used as a heat shock protein inhibitor to inhibit the expression of heat shock protein 60 (HSP60) to enhance the PTT efficiency. Moreover, the SCV nanozyme exhibited obvious peroxidase-mimic (POD) catalytic activity, which could generate highly toxic free radical ions (˙OH) under acidic conditions. The mild-temperature heat and ˙OH produced by enzymatic catalysis effectively blocked the tumor growth, as verified firmly by in vitro and in vivo tests. Our designed virus-like SCV nanozyme with POD mimic enzyme activity and a mild photothermal effect may provide a new way of thinking about the combination therapy model.