Human colorectal cancer tissue assessment using optical coherence tomography catheter and deep learning. Issue 6 (28th February 2022)

• Record Type: Journal Article
• Authors: Luo, Hongbo; Li, Shuying; Zeng, Yifeng; Cheema, Hassam; Otegbeye, Ebunoluwa; Ahmed, Safee; Chapman, William C.; Mutch, Matthew; Zhou, Chao; Zhu, Quing
• Is Part Of: Journal of biophotonics. Volume 15:Issue 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-02-28
• Subjects: catheter -- colorectal cancer -- deep learning -- optical coherence tomography -- ResNet; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.202100349
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract: Optical coherence tomography (OCT) can differentiate normal colonic mucosa from neoplasia, potentially offering a new mechanism of endoscopic tissue assessment and biopsy targeting, with a high optical resolution and an imaging depth of ~1 mm. Recent advances in convolutional neural networks (CNN) have enabled application in ophthalmology, cardiology, and gastroenterology malignancy detection with high sensitivity and specificity. Here, we describe a miniaturized OCT catheter and a residual neural network (ResNet)‐based deep learning model manufactured and trained to perform automatic image processing and real‐time diagnosis of the OCT images. The OCT catheter has an outer diameter of 3.8 mm, a lateral resolution of ~7 μm, and an axial resolution of ~6 μm. A customized ResNet is utilized to classify OCT catheter colorectal images. An area under the receiver operating characteristic ( ROC ) curve (AUC) of 0.975 is achieved to distinguish between normal and cancerous colorectal tissue images. Abstract : A miniaturized OCT catheter is developed for ex vivo human colorectal tissue imaging. The OCT catheter has an outer diameter of 3.8 mm, a lateral resolution of ~7 μm, and an axial resolution of ~6 μm. By incorporating a customized ResNet classifier, our approach has the potential for real‐time classification of normal and neoplastic human colorectal tissues based on the high‐resolution label‐free OCT images.