Risk factors of first recurrence of Clostridioides difficile infection. (June 2022)

• Record Type: Journal Article
• Authors: Yokoyama, Yuki; Shiota, Arufumi; Asai, Nobuhiro; Koizumi, Yusuke; Yamagishi, Yuka; Sakanashi, Daisuke; Nakamura, Akiko; Suematsu, Hiroyuki; Ohnishi, Masafumi; Mikamo, Hiroshige
• Is Part Of: Anaerobe. Volume 75(2022)
• Publication Date: 2022-06
• Subjects: Clostridioides difficile -- Recurrence -- Risk factor -- Probiotics -- Nasogastric (NG) tube; Anaerobic infections -- Periodicals; Anaerobic bacteria -- Periodicals; Bacterial diseases -- Periodicals; Computer network resources; Anaerobic protozoa -- Periodicals; 579.3
• DOI: 10.1016/j.anaerobe.2022.102556
• Languages: English
• ISSNs: 1075-9964

Abstract

Abstract: Objectives: Clostridioides difficile infection (CDI) often recurs. Approximately 25% of patients have recurrences after the initial treatment, and patients who have relapsed once are more likely to relapse. We aimed to identify the risk factors for initial CDI recurrence. Methods: We performed a retrospective survey of patient backgrounds and treatment-related factors. Risk factors were analyzed using single and multiple logistic regression analyses. Results: A total of 134 patients were included in the study. Prophylactic probiotic use and nasogastric tube feeding were independent risk factors for the initial recurrence of CDI. Patients using prophylactic probiotics had significantly higher recurrence rates than those not using prophylactic probiotics. Conclusion: Prophylactic probiotic use and nasogastric tube placement may be risk factors for the initial recurrence of CDI. It is noteworthy that CDI that occurs during the use of prophylactic probiotics may be prone to recurrence. Highlights: Clostridioides difficile infection (CDI) often recurs after initial treatment. Prophylactic use of probiotic is an independent risk factors for rCDI. Prophylactic antibiotics against CDI increase the recurrence rate. Nasogastric tube feeding is a risk factor for the first recurrence of CDI.