Age-related changes in brain functional networks under multisensory-guided hand movements assessed by the functional near – Infrared spectroscopy. (11th June 2022)

• Record Type: Journal Article
• Authors: Yuan, Xin; Li, Qinbiao; Gao, Yeqin; Liu, Heshan; Fan, Zhijun; Bu, Lingguo
• Is Part Of: Neuroscience letters. Volume 781(2022)
• Publication Date: 2022-06-11
• Subjects: RAD rehabilitation assistive device -- FC functional connectivity -- fNIRS functional near-infrared spectroscopy -- LPFC left prefrontal cortex -- RPFC right prefrontal cortex -- LMC left motor cortex -- RMC right motor cortex -- RTL right temporary lobe -- LTL left temporary lobe -- LOL left occipital lobe cortex -- ROL right occipital lobe cortex -- MSTG Multi-sensory training glove -- NG no-guidance -- VG visual guidance -- AVG audio-visual guidance; Multisensory stimulation -- Functional Near-infrared spectroscopy -- Functional connectivity -- Ageing -- Cortical activation; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2022.136679
• Languages: English
• ISSNs: 0304-3940

Abstract

Highlights: Multisensory stimulation produces a more balanced and widespread activity in the brain's functional network. Older adults show a more balanced network, while young adults still show the co-support between ipsilateral brain regions. LPFC and LMC may be the possible hub of strong connectivity in this multisensory-motor network. Abstract: Objectives: This study aims to explore the age-related effects of hand rehabilitation training under multisensory stimulation interaction on brain functional networks. Methods: A multisensory stimulation training glove (MSTG) was designed to realize 3 sensory guidance modes, namely audio-visual guidance (AVG), visual guidance (VG) and no guidance (NG). This study recruited 20 older subjects as the experimental group and 22 young people as the control group. Functional near-infrared spectroscopy (fNIRS) was used to monitor haemoglobin concentration in the motor cortex (MC), prefrontal cortex (PFC), temporary lo be (TL) and occipital lobe (OL) under three different guidance stages, and further analysed the cortical activation and functional connectivity (FC). Results: Multisensory guidance stage showed more activation and higher FC in all subjects. The activated brain regions of the older subjects showed bilateral activation, which is consistent with the Hemispheric Asymmetry Reduction in Older Adults (HAROLD) model. In terms of brain region coordination, older people have a more balanced and denser functional network in the left and right hemispheres compared to younger people. Meanwhile, multisensory stimulation produced a positive training effect on the number of training and reaction time. Conclusion: Audio-visual combined stimulation had a significant gain effect on hand training at different ages. However, older adults induce a wider range of cortical activations. At the same time, young and older people have different intercortical coordination networks. All these results provide theoretically and applied references for multisensory stimulation in the prevention and rehabilitation of ageing and brain neurological disorders.