Does the antenatal detection of fetal growth restriction (FGR) have a prognostic value for mortality and short-term morbidity for very preterm infants? Results from the MOSAIC cohort. (16th February 2016)

• Record Type: Journal Article
• Authors: El Ayoubi, Mayass; Jarreau, Pierre-Henri; Van Reempts, Patrick; Cuttini, Marina; Kaminski, Monique; Zeitlin, Jennifer
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 29:Number 4(2016)
• Page Start: 596
• Page End: 601
• Publication Date: 2016-02-16
• Subjects: Birthweight percentile -- bronchopulmonary dysplasia -- fetal growth restriction -- in-hospital mortality -- preterm infants -- severe neurological morbidity; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2015.1012062
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective : We investigated the impact of antenatal diagnosis of fetal growth restriction (FGR) on the risks of mortality and morbidity for very preterm infants given actual birthweight percentiles. Methods : Data on 4608 live born infants 24–31 weeks of gestational age (GA) in 10 European regions in 2003 were used to compare in-hospital mortality, bronchopulmonary dysplasia (BPD) and severe neurological morbidity by birthweight percentiles and antenatal diagnosis of FGR. Other covariates were GA, sex, multiplicity, maternal complications, antenatal corticosteroids, birth in a level III center and region. Results : Sixteen percent ( n = 728) of all infants and 72%, 30% and 6%, respectively, of those with birthweight percentiles <10th, 10th–24th and ≥25th had an antenatal diagnosis of FGR. After adjustment for clinical factors, antenatal diagnosis of FGR was not associated with mortality for infants with a birthweight ≥10th percentile (OR [95% CI]: 0.9 [0.5–1.9] and 1.0 [0.6–1.8] for birthweights between the 10th–24th percentile and ≥25th percentile, respectively), but infants with a birthweight <10th percentile had higher mortality (OR [95% CI]: 2.4 [1.0–5.8]). No association was observed at any birthweight percentile with BPD or severe neurological morbidity. Conclusion : Antenatal diagnosis of FGR did not influence risks of mortality or morbidity when birthweight was ≥10th percentile; however, mortality risk was higher in antenatally detected infants with birthweight below the <10th percentile.