Mechanochemical Transformation of CF3 Group: Synthesis of Amides and Schiff Bases. Issue 24 (12th October 2021)

• Record Type: Journal Article
• Authors: Mkrtchyan, Satenik; Jakubczyk, Michał; Lanka, Suneel; Yar, Muhammad; Ayub, Khurshid; Shkoor, Mohanad; Pittelkow, Michael; Iaroshenko, Viktor O.
• Is Part Of: Advanced synthesis & catalysis. Volume 363:Issue 24(2021)
• Page Start: 5448
• Page End: 5460
• Publication Date: 2021-10-12
• Subjects: Fluorine -- Ytterbia -- Mechanochemistry -- C−F bond activation -- Methodology; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.202100538
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: We communicate two mild, solvent‐free mechanochemical coupling transformations of CF3 group with nitro compounds into amides or Schiff bases employing Ytterbia as a catalyst. This process proceeds via C−F bond activation, accompanied with utilisation of Si‐based reductants/oxygen scavengers – reductants of the nitro group. The scope and limitations of the disclosed methodologies are thoroughly studied. To the best of our knowledge, this work is the first example of mechanical energy promoted transformation of the inert CF3 group into other functionalities. Abstract :