Copper‐Catalyzed Oxidative Cross‐Coupling of Electron‐Deficient Polyfluorophenylboronate Esters with Terminal Alkynes. Issue 71 (9th November 2020)

• Record Type: Journal Article
• Authors: Liu, Zhiqiang; Budiman, Yudha P.; Tian, Ya‐Ming; Friedrich, Alexandra; Huang, Mingming; Westcott, Stephen A.; Radius, Udo; Marder, Todd B.
• Is Part Of: Chemistry. Volume 26:Issue 71(2020)
• Page Start: 17267
• Page End: 17274
• Publication Date: 2020-11-09
• Subjects: boronate esters -- coupling reactions -- fluorine -- fluoroarenes -- Sonogashira reaction; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202002888
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: We report herein a mild procedure for the copper‐catalyzed oxidative cross‐coupling of electron‐deficient polyfluorophenylboronate esters with terminal alkynes. This method displays good functional group tolerance and broad substrate scope, generating cross‐coupled alkynyl(fluoro)arene products in moderate to excellent yields. Thus, it represents a simple alternative to the conventional Sonogashira reaction. Abstract : BFF : A mild procedure is reported for the synthesis of alkynyl(fluoro)arenes via copper‐catalyzed oxidative cross‐coupling of polyfluorophenylboronate esters with terminal alkynes.