A dynamic compartmental model for the Middle East respiratory syndrome outbreak in the Republic of Korea: A retrospective analysis on control interventions and superspreading events. (7th November 2016)

• Record Type: Journal Article
• Authors: Lee, Jonggul; Chowell, Gerardo; Jung, Eunok
• Is Part Of: Journal of theoretical biology. Volume 408(2016)
• Page Start: 118
• Page End: 126
• Publication Date: 2016-11-07
• Subjects: MERS -- Superspreader -- Nosocomial infections -- Mathematical modeling -- Republic of Korea -- Infectious diseases; Biology -- Periodicals; Biological Science Disciplines -- Periodicals; Biology -- Periodicals; Biologie -- Périodiques; Theoretische biologie; Biology; Periodicals; 571.05
• DOI: 10.1016/j.jtbi.2016.08.009
• Languages: English
• ISSNs: 0022-5193

Abstract

Abstract: The 2015 Middle East respiratory syndrome (MERS) outbreak in the Republic of Korea has provided an opportunity to improve our understanding of the spread of MERS linked to healthcare settings. Here we designed a dynamic transmission model to analyze the MERS outbreak in the Republic of Korea based on confirmed cases reported during the period May 20–July 4, 2015. Our model explicitly incorporates superspreading events and time-dependent transmission and isolation rates. Our model was able to provide a good fit to the trajectory of the outbreak and was useful to analyze the role of hypothetical control scenarios. Specifically, we assessed the impact of the timing of control measures, especially associated with a reduction of the transmission rate and diagnostic delays on outbreak size and duration. Early interventions within 1 week after the epidemic onset, for instance, including the initial government announcement to the public about the list of hospitals exposed to MERS coronavirus (MERS-CoV), show a promising means to reduce the size ( > 71 % ) and duration ( > 35 % ) of the MERS epidemic. Finally, we also present results of an uncertainty analysis focused on the role of superspreading events. Abstract : Highlights: A dynamic transmission model for the 2015 MERS outbreak in the Republic of Korea is proposed. Our model incorporates the superspreading events by pulses of infections. We explore the impact of the timing for hypothetical control scenarios. We analyze uncertainties focused on the role of superspreading events.