Modeling neurodegenerative disorders in zebrafish. (July 2022)

• Record Type: Journal Article
• Authors: Bashirzade, Alim A.; Zabegalov, Konstantin N.; Volgin, Andrey D.; Belova, Alisa S.; Demin, Konstantin A.; de Abreu, Murilo S.; Babchenko, Vladislav Ya.; Bashirzade, Kseniya A.; Yenkoyan, Konstantin B.; Tikhonova, Maria A.; Amstislavskaya, Tamara G.; Kalueff, Allan V.
• Is Part Of: Neuroscience and biobehavioral reviews. Volume 138(2022)
• Publication Date: 2022-07
• Subjects: Neurodegenerative disorders -- Dementia -- Rodents -- Zebrafish -- Cognitive deficits; Psychophysiology -- Periodicals; Human behavior -- Periodicals; Animal behavior -- Periodicals; Neurology -- Periodicals; Behavior -- Periodicals; Ethology -- Periodicals; Neurology -- Periodicals; Psychophysiologie -- Périodiques; Comportement humain -- Périodiques; Animaux -- Mœurs et comportement -- Périodiques; Neurologie -- Périodiques; Animal behavior; Human behavior; Neurology; Psychophysiology; Periodicals; Electronic journals; 573.8
• DOI: 10.1016/j.neubiorev.2022.104679
• Languages: English
• ISSNs: 0149-7634

Abstract

Abstract: Neurodegeneration is a major cause of Alzheimer's, Parkinson's, Huntington's, multiple and amyotrophic lateral sclerosis, pontocerebellar hypoplasia, dementia and other related brain disorders. Their complex pathogenesis commonly includes genetic and neurochemical deficits, misfolded protein toxicity, demyelination, apoptosis and mitochondrial dysfunctions. Albeit differing in specific underlying mechanisms, neurodegenerative disorders typically display evolutionarily conserved mechanisms across taxa. Here, we review the role of zebrafish models in recapitulating major human and rodent neurodegenerative conditions, demonstrating this species as a highly relevant experimental model for research on neurodegenerative diseases, and discussing how these fish models can further clarify the underlying genetic, neurochemical, neuroanatomical and behavioral pathogenic mechanisms. Highlights: Zebrafish is a highly relevant model species in neurodegenerative research. Zebrafish models can help clarify key pathogenic mechanisms of neurodegeneration. Neurodegenerative disorders have evolutionarily conserved mechanisms across taxa. Neurodegeneration involves complex genetic and molecular deficits across taxa.