A classification of MRI brain tumor based on two stage feature level ensemble of deep CNN models. (July 2022)

• Record Type: Journal Article
• Authors: Aurna, Nahid Ferdous; Yousuf, Mohammad Abu; Taher, Kazi Abu; Azad, A.K.M.; Moni, Mohammad Ali
• Is Part Of: Computers in biology and medicine. Volume 146(2022)
• Publication Date: 2022-07
• Subjects: Brain tumor classification -- Convolutional neural network -- Two stage ensemble -- Magnetic resonance imaging -- Principal component analysis; Medicine -- Data processing -- Periodicals; Biology -- Data processing -- Periodicals; 610.285
• DOI: 10.1016/j.compbiomed.2022.105539
• Languages: English
• ISSNs: 0010-4825

Abstract

Abstract: The brain tumor is one of the deadliest cancerous diseases and its severity has turned it to the leading cause of cancer related mortality. The treatment procedure of the brain tumor depends on the type, location and size of the tumor. Relying solely on human inspection for precise categorization can lead to inevitably dangerous situation. This manual diagnosis process can be improved and accelerated through an automated Computer Aided Diagnosis (CADx) system. In this article, a novel approach using two-stage feature ensemble of deep Convolutional Neural Networks (CNN) is proposed for precise and automatic classification of brain tumors. Three unique Magnetic Resonance Imaging (MRI) datasets and a dataset merging all the unique datasets are considered. The datasets contain three types of brain tumor (meningioma, glioma, pituitary) and normal brain images. From five pre-trained models and a proposed CNN model, the best models are chosen and concatenated in two stages for feature extraction. The best classifier is also chosen among five different classifiers based on accuracy. From the extracted features, most substantial features are selected using Principal Component Analysis (PCA) and fed into the classifier. The robustness of the proposed two stage ensemble model is analyzed using several performance metrics and three different experiments. Through the prominent performance, the proposed model is able to outperform other existing models attaining an average accuracy of 99.13% by optimization of the developed algorithms. Here, the individual accuracy for Dataset 1, Dataset 2, Dataset 3, and Merged Dataset is 99.67%, 98.16%, 99.76%, and 98.96% respectively. Finally a User Interface (UI) is created using the proposed model for real time validation. Highlights: Present a new two-stage ensemble approach for multi-classification of brain tumors. CNN models and classifiers are selected through experiments and trials to build the two-stage ensemble model. Model's robustness is assured by three different experiments on the datasets. Evaluation and validation are done through comparative analysis and real-time performance.