Bis‐cyclometalated Iridium Complexes Containing Modified Phenanthroline Ligands and Evaluation of their Cytotoxic Activities. Issue 4 (11th November 2020)

• Record Type: Journal Article
• Authors: Graf, Marion; Böttcher, Hans‐Christian; Sünkel, Karlheinz; Thavalingam, Sugina; Metzler‐Nolte, Nils; Czerwieniec, Rafał
• Is Part Of: Zeitschrift für anorganische und allgemeine Chemie. Volume 647:Issue 4(2021)
• Page Start: 306
• Page End: 311
• Publication Date: 2020-11-11
• Subjects: Bioorganometallic chemistry -- Cyclometalated complexes -- Iridium -- Organometallic anticancer drugs; Chemistry, Inorganic -- Periodicals; Chemistry -- Periodicals; 540
• DOI: 10.1002/zaac.202000287
• Languages: English
• ISSNs: 0044-2313

Abstract

Abstract : The synthesis and characterization of new bis‐cyclometalated complex salts [Ir(ptpy)2 (Lphen )]PF6 with Lphen = 2, 9‐dimethyl‐4, 7‐bis(pentyloxy)‐1, 10‐phenanthroline (1 ) and Lphen = 2, 9‐dimethyl‐4, 7‐bis(2‐ethoxyethoxyl)‐1, 10‐phenanthroline (2 ) are described. Compounds 1 and 2 were obtained by the reaction of the corresponding phenanthroline ligands with [{Ir(μ‐Cl)(ptpy)2 }2 ] in a refluxing CH2 Cl2 /MeOH mixture. The molecular structure of compound 2 was confirmed by single‐crystal X‐ray structure determination. Complex 2 was crystallized from dichloromethane/methanol/ iso ‐hexane in the monoclinic space group P 21 / c . The biological activity of both new compounds was examined, and they exhibit significant cytotoxicity against human cancer cell lines with the IC50 values around 2 μM, significantly better than the established anticancer drug cisplatin under identical conditions. Abstract :