ILAE definition of the Idiopathic Generalized Epilepsy Syndromes: Position statement by the ILAE Task Force on Nosology and Definitions. Issue 6 (3rd May 2022)

• Record Type: Journal Article
• Authors: Hirsch, Edouard; French, Jacqueline; Scheffer, Ingrid E.; Bogacz, Alicia; Alsaadi, Taoufik; Sperling, Michael R.; Abdulla, Fatema; Zuberi, Sameer M.; Trinka, Eugen; Specchio, Nicola; Somerville, Ernest; Samia, Pauline; Riney, Kate; Nabbout, Rima; Jain, Satish; Wilmshurst, Jo M.; Auvin, Stephane; Wiebe, Samuel; Perucca, Emilio; Moshé, Solomon L.; Tinuper, Paolo; Wirrell, Elaine C.
• Other Names: Adikaibe Drs Birinus investigator.; Al Baradi Raidah investigator.; Andrade Danielle investigator.; Bast Thomas investigator.; Beydoun Ahmed investigator.; Bien Christian investigator.; Caraballo Roberto investigator.; Carolina Coan Ana investigator.; Connolly Mary investigator.; Dunne John investigator.; Haut Sheryl investigator.; Jansen Floor investigator.; Jobst Barbara investigator.; Kalviainen Reetta investigator.; Kakooza Angela investigator.; Kato Mitsuhiro investigator.; Knupp Kelly investigator.; Kochen Silvia investigator.; Lagae Lieven investigator.; Carlos Mayor Luis investigator.; Okujava Natela investigator.; Radakishnan Kurupath investigator.; Roulet‐Perez Eliane investigator.; Rios Loreto investigator.; Sadleir Lynette investigator.; Juan‐Orta Daniel San investigator.; Serratosa Jose investigator.; Shellhaas Renee investigator.; Tsai Meng‐Han investigator.; Udani Vrajesh investigator.; Yue‐Hua Zhang, Helen investigator.; Zhou. Dong investigator.;
• Is Part Of: Epilepsia. Volume 63:Issue 6(2022)
• Page Start: 1475
• Page End: 1499
• Publication Date: 2022-05-03
• Subjects: absence seizures -- childhood absence epilepsy -- generalized tonic–clonic seizures -- generalized tonic–clonic seizures alone -- genetic generalized epilepsy -- juvenile absence epilepsy -- juvenile myoclonic epilepsy -- myoclonic seizures; Epilepsy -- Periodicals; 616.853
• DOI: 10.1111/epi.17236
• Languages: English
• ISSNs: 0013-9580

Abstract

Abstract: In 2017, the International League Against Epilepsy (ILAE) Classification of Epilepsies described the "genetic generalized epilepsies" (GGEs), which contained the "idiopathic generalized epilepsies" (IGEs). The goal of this paper is to delineate the four syndromes comprising the IGEs, namely childhood absence epilepsy, juvenile absence epilepsy, juvenile myoclonic epilepsy, and epilepsy with generalized tonic–clonic seizures alone. We provide updated diagnostic criteria for these IGE syndromes determined by the expert consensus opinion of the ILAE's Task Force on Nosology and Definitions (2017–2021) and international external experts outside our Task Force. We incorporate current knowledge from recent advances in genetic, imaging, and electroencephalographic studies, together with current terminology and classification of seizures and epilepsies. Patients that do not fulfill criteria for one of these syndromes, but that have one, or a combination, of the following generalized seizure types: absence, myoclonic, tonic‐clonic and myoclonic‐tonic‐clonic seizures, with 2.5–5.5 Hz generalized spike‐wave should be classified as having GGE. Recognizing these four IGE syndromes as a special grouping among the GGEs is helpful, as they carry prognostic and therapeutic implications.