Cytotoxic Diterpenoids from Euphorbia fischeriana. Issue 2 (2nd February 2021)

• Record Type: Journal Article
• Authors: Meng, Jia; Li, Bo‐Ting; Sheng, Gang; Zhang, An‐Ling; Li, Xing‐Cong; Tian, Jun‐Mian
• Is Part Of: Chemistry & biodiversity. Volume 18:Issue 2(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-02-02
• Subjects: diterpenoids -- euphorfischerins -- Euphorbiaceae -- Euphorbia fischeriana -- cytotoxic activities; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Biodiversity -- Periodicals; 572
• DOI: 10.1002/cbdv.202000919
• Languages: English
• ISSNs: 1612-1872

Abstract

Abstract: Five new diterpenoids, named euphorfischerins A–E, were isolated from the roots of Euphorbia fischeriana . Their chemical structures and absolute configurations were determined by interpretation of NMR, HR‐ESI‐MS, ECD and X‐ray diffraction data. Euphorfischerin A showed cytotoxicity against the human cancer cell lines HeLa, H460 and Namalwa with IC50 values of 4.6, 11.5 and 16.4 μM, respectively, while euphorfischerin B gave comparable IC50 values of 9.5, 17.4 and 13.3 μM against the three cancer cell lines, respectively. Abstract :