LncRNAs and CircRNAs in cancer. Issue 2 (12th May 2022)

• Record Type: Journal Article
• Authors: Yin, Xin; Lin, Huiran; Lin, Lei; Miao, Lei; He, Jing; Zhuo, Zhenjian
• Is Part Of: MedComm. Volume 3:Issue 2(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-12
• Subjects: cancer -- circRNAs -- lncRNAs -- neuroblastoma; 610
• DOI: 10.1002/mco2.141
• Languages: English
• ISSNs: 2688-2663

Abstract

Abstract: It is well known that noncoding RNAs (ncRNAs) cannot encode proteins, but they can play important regulatory roles in tumors by combining with proteins, RNAs, and DNAs. As more and more studies reveal the important roles and underlying mechanisms of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) in cancer, their huge application potential in cancer therapy cannot be ignored. For example, lncRNAs can be involved in tumor‐related signal transduction pathways, cell cycle control, DNA damage, epigenetic regulation, and microRNA control. A group of studies confirmed that abnormal expression of lncRNAs can affect cancer progression. Furthermore, as covalently closed continuous circular ncRNAs, many recent studies have shown that circRNAs have regulatory effects and other important biological significances in cancer. Interestingly, circRNAs were found to have translational functions. This has greatly attracted people's attention to circRNAs research. In this review, we introduce the important roles of lncRNAs and circRNAs in some representative cancers, respectively. Furthermore, we focus on the biological functions and important clinical therapeutic implications of lnRNAs and circRNAs in neuroblastoma. Our review also focuses on providing rationale and relevant references for novel biomarkers for neuroblastoma diagnosis, prognosis, and treatment. Abstract : In this study, we comprehensively summarized the latest insights into the lncRNAs in cancer especially neuroblastoma by their functions (i.e., survival rate, proliferation, apoptosis, differentiation, cell cycle, migration, invasion, metastasis, glycolysis, DNA methylation, drug resistance, and susceptibility). The potential clinical applications of lncRNAs as prospective novel biomarkers and therapeutic targets of neuroblastoma were also discussed. In addition, we also briefly highlighted the functions of circular RNAs (circRNAs) in cancer especially neuroblastoma. This review provides a comprehensive landscape of lncRNAs and circRNAs in cancer especially neuroblastoma.