Trends in sarcoidosis mortality rate in Japan from 2001 to 2020: A population-based study. (May 2022)

• Record Type: Journal Article
• Authors: Harada, Ko; Hagiya, Hideharu; Koyama, Toshihiro; Otsuka, Fumio
• Is Part Of: Respiratory medicine. Volume 196(2022)
• Publication Date: 2022-05
• Subjects: Sarcoidosis -- Trend analysis -- Sarcoidosis mortality rate -- Geriatrics -- Aging; Chest -- Diseases -- Periodicals; Chest -- Diseases -- Great Britain -- Periodicals; Respiratory organs -- Diseases -- Periodicals; Respiratory Tract Diseases -- Periodicals; Appareil respiratoire -- Maladies -- Périodiques; Thorax -- Maladies -- Périodiques; Appareil respiratoire -- Maladies -- Traitement -- Périodiques; Electronic journals; 616.2
• DOI: 10.1016/j.rmed.2022.106828
• Languages: English
• ISSNs: 0954-6111

Abstract

Abstract: Background: The sarcoidosis mortality rate has increased over the years, which contributes to the health care burden. Although epidemiological studies of sarcoidosis mortality in aging societies are essential, none have been published since 1989 in Japan. Methods: We aimed to investigate the trends in crude and age-adjusted sarcoidosis-associated mortality rates per 1, 000, 000 population in Japan from 2001 to 2020 using national death certificate data among older adults aged over 50 years. The data were analysed using the joinpoint regression models to estimate long-term trends and average annual percentage changes (AAPCs). Results: A total of 3094 sarcoidosis-associated deaths were recorded from 2001 to 2020 in Japan; women constituted 65.3% of these, with a female:male ratio of 1.89. Nearly 80% of deaths were over the age of 65 years, of which 32% were over the age of 80 years. The trend in crude mortality of those aged ≥80 years markedly increased from 0.81 to 9.68 per 1, 000, 000 population in men and from 2.38 to 12.87 in women, respectively. The overall age-adjusted sarcoidosis mortality rate increased 2.46-fold during the study period, with an AAPC of 5.1%. Conclusions: This study revealed that sarcoidosis-associated deaths in Japan have significantly increased over the past two decades, especially among the older population with a female predominance. Given the rising mortality rate and susceptibility of the older population, sarcoidosis will require more attention from health care providers in terms of a multidisciplinary approach to address the specific needs of the older population. Highlights: Age-adjusted sarcoidosis mortality rate in Japan has increased 2.46-fold. Nearly 80% of deaths were over the age of 65 years. Given a susceptible older adult population, sarcoidosis requires greater attention. Abstract : Take home message: Sarcoidosis mortality in Japan has significantly increased over the past 20 years among the older population with a female predominance. Given the increased mortality and a susceptible older population, it requires greater attention from clinicians.