Age‐related memory vulnerability to interfering stimuli is caused by gradual loss of MAPK‐dependent protection in Drosophila. Issue 6 (15th May 2022)

• Record Type: Journal Article
• Authors: Mo, Han; Wang, Linghan; Chen, Yuting; Zhang, Xuchen; Huang, Ning; Liu, Tingting; Hu, Wantong; Zhong, Yi; Li, Qian
• Is Part Of: Aging cell. Volume 21:Issue 6(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-15
• Subjects: aging -- Drosophila -- interference -- MAPK -- memory -- protection -- vulnerability; Cells -- Aging -- Periodicals; 571.8783605
• DOI: 10.1111/acel.13628
• Languages: English
• ISSNs: 1474-9718

Abstract

Abstract: Age‐related memory impairment (AMI) is a common phenomenon across species. Vulnerability to interfering stimuli has been proposed to be an important cause of AMI. However, the molecular mechanisms underlying this vulnerability‐related AMI remain unknown. Here we show that learning‐activated MAPK signals are gradually lost with age, leading to vulnerability‐related AMI in Drosophila . Young flies (2‐ or 3‐day‐old) exhibited a significant increase in phosphorylated MAPK levels within 15 min after learning, whereas aged flies (25‐day‐old) did not. Compared to 3‐day‐old flies, significant 1 h memory impairments were observed in 15‐, 20‐, and 30‐day‐old flies, but not in 10‐day‐old flies. However, with post‐learning interfering stimuli such as cooling or electric stimuli, 10‐day‐old flies had worse memory performance at 1 h than 3‐day‐old flies, showing a premature AMI phenomenon. Increasing learning‐activated MAPK signals through acute transgene expression in mushroom body (MB) neurons restored physiological trace of 1 h memory in a pair of MB output neurons in aged flies. Decreasing such signals in young flies mimicked the impairment of 1 h memory trace in aged flies. Restoring learning‐activated MAPK signals in MB neurons in aged flies significantly suppressed AMI even with interfering stimuli. Thus, our data suggest that age‐related loss of learning‐activated neuronal MAPK signals causes memory vulnerability to interfering stimuli, thereby leading to AMI. Abstract : Learning‐activated MAPK signals are reported to protect labile memory in Drosophila. Such protective signals are gradually lost with age, making labile memory more vulnerable to interfering stimuli, which can lead to age‐related memory impairment (AMI). Acutely restoring learning‐activated MAPK signals in mushroom body neurons in aged flies significantly suppresses AMI even with interfering stimuli.