Comparison of tomographic kidney volumes measured by semiautomatic segmentation method with scintigraphic split renal function in predicting posttransplant kidney functions. (14th April 2022)

• Record Type: Journal Article
• Authors: Yılmaz, Vural T.; Tulum, Gökalp; Dandin, Özgür; Kısaoğlu, Abdullah; Cüce, Ferhat; Ergin, Tuncer; Özel, Deniz; Demiryılmaz, İsmail; Koçak, Hüseyin; Aydınlı, Bülent; Osman, Onur
• Is Part Of: Clinical physiology and functional imaging. Volume 42:Number 4(2022)
• Page Start: 250
• Page End: 259
• Publication Date: 2022-04-14
• Subjects: CT volumetry -- graft functions -- renal transplantation -- scintigraphic split renal functions; Physiology, Pathological -- Periodicals; Diagnostic imaging -- Periodicals; 612
• DOI: 10.1111/cpf.12754
• Languages: English
• ISSNs: 1475-0961

Abstract

Abstract: Introduction: In this study, it was aimed to compare scintigraphic split renal function (SRF) and computed tomographic (CT) kidney volumes by semiautomatic segmentation method in predicting graft functions after kidney transplantation. Methods: One hundred and twelve patients (77 males, 35 females) who had a living‐donor kidney transplant between 2015 and 2017 in our centre were included in the study. While SRF was calculated with technetium‐99m‐diethylenetriaminepentaacetic acid ( 99m Tc‐DTPA) scintigraphy, CT angiography was used for volumetric calculations. Results: CT‐volumetric measurements, especially renal cortical volume (RCV: 103.8 ± 20 ml) and ratio to body mass index (RCV/BMI: 4.45 ± 1.3) were found to be more significant than 99m Tc‐DTPA‐SRF in predicting graft functions. The correlations between SRF and RCV with 6th‐month estimated glomerular filtration rate (eGFR) (rSRF: 0.052, rRCV: 0.317, p = 0.041) and 1st‐year eGFR (rSRF: 0.104, rRCV: 0.374, p = 0.033) were found to be more significant in favour of RCV. The correlation between SRF/BMI and RCV/BMI with 1st‐, 6th‐ and 12th‐month eGFR (respectively, p = 0.02/0.048/0.024) were found to be more significant in favour of RCV/BMI. Although univariate analysis showed a significant relationship between most volumetric measurements and 1st‐year graft functions, in multivariate analysis only RCV [odds ratio (OR): 1.04 (1.01–1.07), p = 0.023] and RCV/BMI [OR: 2.5 (1.27–5.39), p = 0.013] showed a significant relationship between graft functions. Conclusion: In our study, it was shown that CT‐based renal volumetric measurements, especially RCV and RCV/BMI, predicted graft functions more strongly than scintigraphic 99m Tc‐DTPA‐SRF.